Inclusion Criteria:
Age 21-85
Single, monolateral nodule visible on chest CT scan (with or without contrast) suspicious for lung cancer.
MSK radiologist report or read suggestive of suspected primary lung cancer.
Pulmonary function test results indicating the patient is eligible for subsequent diagnostic procedures (FEV1 >50%, DLco >50%).
Negative test for COVID-19, done as part of standard of care testing (locally or at MSK) prior to biopsy or surgical procedure
Eligible for fine-needle aspiration biopsy and/or surgical resection for diagnosis (i.e., does not have comorbidities precluding these).
Documented, signed, and dated informed consent, obtained before any procedures, for the proposed research study, and signed standard surgical consent for fine-needle aspiration biopsy and/or surgical resection for diagnosis.
Exclusion Criteria:
Age 85 years at first outpatient visit.
Multiple ipsilateral or bilateral nodules reported on chest CT scan and/or concurrent semisolid GGOs.
History of thoracic or extrathoracic cancer that puts the subject at risk for pulmonary metastases.
Metastatic lung cancer disease seen on chest CT or PET scan at hilar/mediastinal nodes or contralateral lung or extrathoracic sites.
Marginal cardiorespiratory function (FEV1
