If you are interested in participating in the trial:-
This clinical trial will involve you staying with us for a few days (see below) at our private clinical research unit in London Bridge.
You will need to attend a screening appointment so we can check if you are suitable to take part in the trial. At this appointment we perform a number of tests including, taking blood, checking your heart, and carrying out a physical examination to see if you will be OK to take part in the clinical trial. Eligible participants may also need to have a liver biopsy.
If results from your screening appointment show you are suitable for the trial, you will be invited to take part.
There may be some times that you will remain overnight for safety or logistical requirements but this will be discussed further during your initial visit. After your stay with us, you will be required to return for further appointments on Day 15, Day 29, Day 43, Day 57, Day 99, Day 113, Day 169, Day 225, Day 281, and Day 337 of the trial. This means the whole trial takes approximately 14 and a half months from your screening visit through to your final visit.
In total, if you are included in the clinical trial you will come to the research unit 13 times.
During your stay with us, you will receive two doses (on Day 1 and Day 85) of the investigational medicine subcutaneously (i.e. injection just under the skin) and we will conduct a number of assessments (like those we did at screening) to check how well you tolerate the new medicine and to help us understand how long it takes for your body to get rid of the new medicine and how effective the new drug is in reducing the amount of the target protein in the blood.